Senior Specialist, Genetic Analysis

Exciting Opportunity at MSK:The Diagnostic Molecular Genetics Laboratory at Memorial Sloan Kettering Cancer Center is seeking a Senior Genetic Analysis Specialist to join a world-class clinical team focused on interpreting and classifying germline genetic variants that guide inherited cancer risk assessment and support patient care.This position offers the unique opportunity to work at the crossroads of clinical diagnostics,cuttingedgeresearch, and advanced genomic analysis-making a meaningful impactinprecision oncology.

Role Overview:

• Interpret and classify germline genetic variantsidentifiedthrough clinical next-generation sequencing (NGS) using AMP / ACMG guidelines with established genomic databases.

• Review NGS pipeline output for sample quality, accuracy,relevantgenetic history,and sequencing artifacts;initiateconfirmatory testing as needed.

• Collaborate closely with molecular pathologists, geneticists,genetic counselors,and bioinformaticiansto draft andfinalizeclinical reports.

• Support laboratoryoperationsunder supervision,by contributing to workflow optimization, SOP development, and NYSDOH validation submissions.

• Train, mentor, and assess competency ofpeeranalysts, new,and rotating staff in germline variant interpretation.

• Participate in translational research initiatives, data sharing efforts (e.g.ClinVar), and quality improvement projects.

• Assistwith evaluating, testing,and integrating newvariantanalytical tools and databases into clinical workflows.

• Support regulatory inspections, as needed, to ensureclinical laboratorycompliance with data security,clinical documentation,and HIPAA standards.

Key Qualifications:

• Master’s degree in HumanGenetics, Genetics,Genetic Counseling,Cancer Biology, Molecular Biologyrequired.

• PhD in Human Genetics, Genetics, Cancer Biology or Molecular Biologyispreferred.

• Comprehensiveknowledge,anddemonstratedproficiencytowardsinterpreting germline variants in a clinicallaboratoryand/or cancer genetics setting.

• Strong foundationin human genetics and the molecular biology of cancer susceptibility genes.

• Experience with germline genetic databases and cancer predisposition variant analysis tools.

• Demonstrated ability to critically evaluate scientific literature and apply findings to clinical variant interpretation.

Core Skills:

• Advanced Analytical & Critical Thinking – Interprets complex genomicdata and applies evidence-based reasoning to variant analysis.

• Molecular & Germline Genetics Knowledge – experience with molecular lab workflows, germline cancer genetics, and clinical laboratory regulations.

• Genomic & Bioinformatics Knowledge –Experience withNGS, Sanger Sequencing and MLPA datainterpretation,relevantclinical analysis tools, and bioinformatics software/databases.

• ExpertScientific Literacy – Ability to critically read, interpret, and apply findings from scientific literature to clinical practice and variant curation.

• Communication & Knowledge Sharing – Excellent written,verbal, andpresentationskills;ability to train and collaborateeffectivelyacross multidisciplinary teams.

Additional Information:

• Location: Schwartz Building, 1250 First Avenue, New York, NY

• Schedule: Monday – Friday, 9 am – 5 pm

• Reports to:Pathology and Laboratory MedicineSupervisor, Molecular Diagnostic Lab

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